刘光慧

刘光慧，博士，研究员，中国医学科学院学部委员，中国科学院动物研究所学术委员会副主任，膜生物学国家重点实验室副主任，中国科学院干细胞与再生医学科学数据中心主任，北京干细胞与再生医学研究院副院长、学术委员会主任，国家自然科学基金委创新研究群体项目负责人，杰出青年基金项目获得者。2023年1月8日，中国科学院动物研究所研究员刘光慧研究还证明抑制这些基因的“复活”，能延缓组织和机体的衰老。相关研究在线发表在《细胞》杂志上。

基本资料

中文名：刘光慧

国籍：中国

出生日期：1979年

毕业院校：北京大学医学部、中国科学院生物物理研究所

出生地：辽宁省

性别：男

学位：博士

人物经历

2002年毕业于北京大学医学部，获理学学士学位；2007年于中国科学院生物物理研究所获得理学博士学位；2007-2012年先后在美国斯克利普斯研究所（TheScrippsResearchInstitute）和索尔克生物学研究所（SalkInstituteforBiologicalStudies）从事博士后（ResearchAssociate）研究；2012年加入中国科学院生物物理研究所，任研究员（PI）；2019年至今任中国科学院动物研究所研究员（PI）。

研究领域

1.人类衰老的遗传和表观遗传信息解码

结合灵长类动物模型、人干细胞、基因编辑、全基因组筛选、单细胞测序、多组学分析及人工智能，研究人类衰老和老年疾病的遗传和表观遗传学基础，探索延缓衰老（如脑衰老和心血管衰老）和防治老年疾病（如神经退行性疾病和动脉粥样硬化症）的方法和手段，以期实现健康老龄化（healthyaging）的目标。

2.基于干细胞技术的人类疾病机理研究和精准治疗

利用患者诱导性多能干细胞（iPSC）和体外创建的疾病胚胎干细胞（ESC），结合细胞、类器官定向分化和移植技术，在功能基因组水平研究人类疾病的分子机理及新型靶标；发展基于干细胞技术的药物筛选和评价体系；研发针对器官衰老和特定疾病靶标的候选药物（化合物）；推动干细胞和衰老相关技术的临床转化。

3.新型基因编辑手段和基因治疗技术的发展和应用

以HDAdV、telHDAdV、TTALE和CRISPR/Cas9为基础，发展安全高效地编辑人类基因组的新方法，开发以去衰老和促再生为目标的干细胞和基因治疗新策略，为罕见疾病的基因修复、人类干细胞的遗传增强、以及衰老相关疾病的干预提供科学依据。

社会任职

国际健康与寿命研究学会（AHLR）创会理事，中国科协第十届常委会青年科技工作者专委会委员，中国细胞生物学学会衰老细胞生物学分会创会会长，中国老年学和老年医学学会抗衰老分会主任委员，《LifeMedicine》主编，《Protein&Cell》副主编，《CellReports》编委，《PLOSBiology》编委，《AgingCell》编委，《ChinaScienceLifeScience编委》，《BoneResearch》编委，《CellProliferation》编委，《CellRegeneration》编委，《Research》编委，《FundamentalResearch》编委，《CurrentMedicine》编委，《NationalScienceOpen》编委。

所获荣誉

侨界贡献奖一等奖（2022），国家“十三五科技创新成就展”基础研究重大成果（2021），科学探索奖（2021），中华医学科技奖（2021），北京市杰出青年中关村奖（2021），Elsevier中国高被引学者（2021，2020），中国科学十大进展（2020），中国生命科学十大进展（2020），中国科学院杰出科技成就奖（2020），国务院政府特殊津贴（2020），顾孝诚讲座奖（2019），药明康德生命化学研究奖（2019），中源协和生命医学创新突破奖（2019），中国青年科技奖特别奖（2018），谈家桢生命科学创新奖（2018），中国生命科学十大进展（2018），树兰医学青年奖（2017），首届老年医学杰出贡献奖（2017）。

论文著作

LiuX,LiuZ,WuZ,RenJ,FanY,SunL,CaoG,NiuY,ZhangB,JiQ,JiangX,WangC,WangQ,JiZ,LiL,EstebanCR,YanK,LiW,CaiY,WangS,ZhengA,ZhangYE,TanS,CaiY,SongM,LuF,TangF,JiW,ZhouQ,BelmonteJCI,ZhangW*,QuJ*,LiuGH*.Resurrectionofendogenousretrovirusesduringagingreinforcessenescence.Cell.2023.186:1–18.https://doi.org/10.1016/j.cell.2022.12.017.

SunS,MaS,CaiY,WangS,RenJ,YangY,PingJ,WangX,ZhangY,YanH,LiW,EstebanCR,YuY,LiuF,BelmonteJCI,ZhangW*,QuJ*,LiuGH*.ASingle-cellTranscriptomicAtlasofExercise-inducedAnti-inflammatoryandGeroprotectiveEffectsacrosstheBody.Innovation.2023.https://doi.org/10.1016/j.xinn.2023.100380.

MaS,WangS,YeY,RenJ,ChenR,LiW,LiJ,ZhaoL,ZhaoQ,SunG,JingY,ZuoY,XiongM,YangY,WangQ,LeiJ,SunS,LongX,SongM,YuS,ChanP,WangJ,ZhouQ,BelmonteJCI,QuJ*,ZhangW*,LiuGH*.Heterochronicparabiosisinducesstemcellrevitalizationandsystemicrejuvenationacrossagedtissues.CellStemCell.2022.29(6):990-1005.

LiuZ,JiQ,RenJ,YanP,WuZ,WangS,SunL,WangZ,LiJ,SunG,LiangC,SunR,JiangX,HuJ,DingY,WangQ,BiS,WeiG,CaoG,ZhaoG,WangH,ZhouQ,BelmonteJCI,QuJ*,ZhangW*,LiuGH*.Large-ScaleChromatinReorganizationReactivatesPlacenta-SpecificGenesthatDriveCellularAging.DevelopmentalCell.2022.57(11):1347-1368.

ZhaoH,JiQ,WuZ,WangS,RenJ,YanK,WangZ,HuJ,ChuQ,HuH,CaiY,WangQ,HuangD,JiZ,LiJ,BelmonteJCI,SongM*,ZhangW*,QuJ*,LiuGH*.DestabilizingheterochromatinbyAPOEmediatessenescence.NatureAging.2022.2,303–316.

LiangC,KeQ,LiuZ,RenJ,ZhangW,HuJ,WangZ,ChenH,XiaK,LaiX,WangQ,YangK,LiW,WuZ,WangC,YanH,JiangX,JiZ,MaM,LongX,WangS,WangH,SunH,BelmonteJCI,QuJ*,XiangAP*,LiuGH*.BMAL1moonlightingasagatekeeperforLINE1repressionandcellularsenescenceinprimates.NucleicAcidsResearch.2022.50(6):3323-3347.

KangW,JinT,ZhangT,MaS,YanH,LiuZ,JiZ,CaiY,WangS,SongM,RenJ,HuB,ZhouQ,ZhangW*,QuJ*,BaoY*,LiuGH*.RegenerationRoadmap:databaseresourcesforregenerativebiology.NucleicAcidsResearch.2022.50(D1):D1085-D1090.

YanH,WangR,MaS,HuangD,WangS,RenJ,LuC,ChenX,ZhangW*,QuJ*,ZhouY*,LiuGH*.LineageLandscape:Acomprehensivedatabasethatrecordslineagecommitmentacrossspecies.NucleicAcidsResearch.2022.doi:10.1093/nar/gkac951.

LiuZP,LiW,GengL,SunL,WangQ,YuY,YanP,LiangC,RenJ,SongM,ZhaoQ,LeiJ,CaiY,LiJ,YanK,WuZ,ChuQ,LiJ,WangS,LiC,HanJD,Hernandez-BenitezR,Shyh-ChangNg,IzpisuaBelmonteJC,ZhangWQ*,QuJ*,LiuGH*.Cross-speciesmetabolomicanalysisidentifiesuridineasapotentregenerationpromotingfactor.CellDiscovery.2022.1;8(1):6.

ShanH,GengL,JiangX,SongM,WangJ,LiuZ,ZhuoX,WuZ,JiZ,WangS,ChanP,QuJ*,ZhangW*,LiuGH*.Large-ScaleChemicalScreenIdentifiesGallicAcidasaGeroprotectorforHumanStemCells.ProteinCell.2022.13(7):532-539.

JingY,ZuoY,YuY,SunL,YuZR,MaS,ZhaoQ,HuH,LiJ,LiuL,SunG,LiJ,BelmonteJCI,ZhangW*,WangS*,QuJ*,LiuGH*.Single-nucleusProfilingUnveilsaGeroprotectiveRoleoftheFOXO3inPrimateSkeletalMuscleAging.ProteinCell.2022.Doi:10.1093/procel/pwac061.

SunG,ZhengY,FuX,ZhangW,RenJ,MaS,SunS,HeX,WangQ,JiZ,ChengF,YanK,LiuZ,BelmonteJCI,QuJ*,WangS*,ChaiR*,LiuGH*.Single-CellTranscriptomicAtlasofMouseCochlearAging.ProteinCell.2022.DOI:10.1093/procel/pwac058.

YuanB,ZhouX,SuzukiK,Ramos-MandujanoG,WangM,TehseenM,Cortés-MedinaLV,MorescoJJ,DunnS,Hernandez-BenitezR,HishidaT,KimNY,AndijaniMM,BiC,KuM,TakahashiY,XuJ,QiuJ,HuangL,BennerC,AizawaE,QuJ,LiuGH,LiZ,YiF,GhoshehY,ShaoC,ShokhirevM,ComoliP,FrassoniF,YatesJR3rd,FuXD,EstebanCR,HamdanS,LiM,IzpisuaBelmonteJC.Wiskott-Aldrichsyndromeproteinformsnuclearcondensatesandregulatesalternativesplicing.NatureCommunications.2022.13(1):3646.

HishidaT,YamamotoM,Hishida-NozakiY,ShaoC,HuangL,WangC,ShojimaK,XueY,HangY,ShokhirevM,MemczakS,SahuSK,HatanakaF,RosRR,MaxwellMB,ChavezJ,ShaoY,LiaoHK,Martinez-RedondoP,Guillen-GuillenI,Hernandez-BenitezR,EstebanCR,QuJ,HolmesMC,YiF,HickeyRD,GarciaPG,DelicadoEN,CastellsA,CampistolJM,YuY,HargreavesDC,AsaiA,ReddyP,LiuGH,IzpisuaBelmonteJC.Invivopartialcellularreprogrammingenhancesliverplasticityandregeneration.CellReports.2022.39(4):110730.

WangW,ZhengY,SunS,LiW,SongM,JiQ,WuZ,LiuZ,FanY,LiuF,LiJ,EstebanCR,WangS,ZhouQ,BelmonteJCI,ZhangW*,QuJ*,TangF*,LiuGH*.AGenome-wideCRISPR-BasedScreenIdentifiesKAT7asaSenescenceDriver.ScienceTranslationalMedicine.2021.13,Jan6;13(575):eabd2655.

ZouZ,LongX,ZhaoQ,ZhengY,SongM,MaS,WangS,HeY,EstebanCR,HuangJ,YuN,ChanP,BelmonteJCI,ZhangW*,QuJ*,LiuGH*.Asingle-celltranscriptomicatlasofhumanskinaging.DevelopmentalCell.2021.56(3):383-397(Coverstory)

LiangC,LiuZ,SongM,LiW,WuZ,WangZ,WangQ,WangS,YanK,SunL,HishidaT,CaiY,IzpisuaBelmonteJC,GuillenP,ChanP,ZhouQ,ZhangW*,QuJ*,LiuGH*.StabilizationofHeterochromatinbyCLOCKPromotesStemCellRejuvenationandCartilageRegeneration.CellResearch.2021.31(2):187-205.

WangS,YaoX,MaS,PingY,FanY,SunS,HeZ,ShiY,SunL,XiaoS,SongM,CaiJ,LiJ,TangR,ZhaoL,WangC,WangQ,ZhaoL,HuH,LiuX,SunG,ChenL,PanG,ChenH,LiQ,ZhangP,XuY,FengH,ZhaoGG,WenT,YangY,HuangX,LiW,LiuZ,WangH,WuH,HuB,RenY,ZhouQ,QuJ*,ZhangW*,LiuGH*,BianXW*.Asingle-celltranscriptomiclandscapeofthelungsofpatientswithCOVID-19.NatureCellBiology.2021.23(12):1314-1328(Leadingcontact)

ZhangH,LiJ,RenJ,SunS,MaS,ZhangW,YuY,CaiY,YanK,LiW,HuB,ChanP,ZhaoGG,BelmonteJC,ZhouQ,QuJ*,WangS*,LiuGH*.Single-nucleustranscriptomiclandscapeofprimatehippocampalaging.ProteinCell.2021.12(9):695-716.(Coverstory)

AgingAtlasConsortium,ZhangW*,JingQu*,BaoY*,LiuGH*.AgingAtlas:amulti-omicsdatabaseforagingbiology.NucleicAcidsResearch.2021.8;49(D1):D825-D830.

LiH,WeiX,ZhouL,ZhangW,WangC,GuoY,LiD,ChenJ,LiuT,ZhangY,MaS,WangC,TanF,XuJ,LiuY,YuanY,ChenL,WangQ,QuJ,ShenY,LiuS,FanG,LiuL,LiuX,HouY,LiuGH*,GuY*,XuX*.Dynamiccelltransitionandimmuneresponselandscapesofaxolotllimbregenerationrevealedbysingle-cellanalysis.ProteinCell.2021.12(1):57-66.

LiCJ,XiaoY,SunYC,HeWZ,LiuL,HuangM,HeC,HuangM,ChenKC,HouJ,FengX,SuT,GuoQ,HuangY,PengH,YangM,LiuGH,LuoXH.SenescentimmunecellsreleaseGrancalcintopromoteskeletalaging.CellMetabolism.2021.33(10):1957-1973.

WangS,ZhengY,LiJ,YuY,ZhangW,SongM,LiuZ,MinZ,HuH,JingY,HeX,SunL,EstebanC,ChanP,QiaoJ,ZhouQ,BelmonteJC*,JingQu*,TangF*,LiuGH*.Single-CellTranscriptomicAtlasofPrimateOvarianAging.Cell.2020.180(3):585-600.(Coverstory)

MaS,SunS,GengL,SongM,WangW,YeY,JiQ,ZouZ,WangS,HeX,LiW,RodriguezEstebanC,LongX,GuoG,ChanP,ZhouQ,BelmonteJC*,ZhangW*,QuJ*,LiuGH*.CaloricRestrictionReprogramstheSingle-CellTranscriptionalLandscapeofRattusNorvegicusAging.Cell.2020.180(5):984-1001.

MaS,SunS,LiJ,FanY,QuJ,SunL,WangS,ZhangY,YangS,LiuZ,WuZ,ZhangS,WangQ,ZhengA,DuoS,YuY,BelmonteJCI,ChanP,ZhouQ,SongM*,ZhangW*,LiuGH*.Single-CellTranscriptomicAtlasofPrimateCardiopulmonaryAging.CellResearch.2020.10;1-18.

YanP,LiuZ,SongM,WuZ,XuW,LiK,JiQ,WangS,LiuX,YanK,EstebanCR,CiW,IzpisuaBelmonteJC,XieW,RenJ,ZhangW*,SunQ*,QuJ*,LiuGH*.Genome-wideR-looplandscapesduringcelldifferentiationandreprogramming.CellReports.2020.32(1):107870

WangF,ZhangW,YangQ,KangY,FanY,WeiJ,LiuZ,DaiS,LiH,LiZ,XuL,ChuC,QuJ,SiC,JiW*,LiuGH*,LongC*,NiuY*.GenerationofaHutchinson-Gilfordprogeriasyndromemonkeymodelbybaseediting.ProteinCell.2020.11(11):809-824.(Coverstory)

ZhengY,LiuX,LeW,XieL,LiH,WenW,WangS,MaS,HuangZ,YeJ,ShiW,YeY,LiuZ,SongM,ZhangW,BelmonteJCI,XiaoC,QuJ*,WangH*,LiuGH*,SuW*.AhumancirculatingimmunecelllandscapeinagingandCOVID-19.ProteinCell.2020.192:111357.

WangS,MinZ,JiQ,GengL,SuY,LiuZ,HuH,WangL,ZhangW,SuzuikiK,HuangY，ZhangP,TangT,QuJ*,YuY*,LiuGH*,QiaoJ*.RescueofPrematureAgingDefectsinCockayneSyndromeStemCellsbyCRISPR/Cas9-MediatedGeneCorrection.ProteinCell.2020.11(1):1-22.

YanP,LiQ,WangL,LuP,SuzukiK,LiuZ,LeiJ,LiW,RenR,HeX,WangS,DingJ,ChanP,ZhangW,SongM,BelmonteJC,QuJ*,TangF*,LiuGH*.FOXO3-EngineeredHumanESC-DerivedVascularCellsPromoteVascularProtectionandRegeneration.CellStemCell.2019.24(3),447-461.(Coverstory)

DengL,RenR,LiuZ,SongM,LiJ,WuZ,RenX,FuL,LiW,ZhangW,GuillenP,BelmonteJ,ChanP,QuJ*,LiuGH*.StabilizingHeterochromatinbyDGCR8AlleviatesSenescenceandOsteoarthritis.NatureCommunications.2019.10(1):3329.

ChengF,WangS,SongM,LiuZ,LiuP,ChanP,WangY,WangL,ZhangW*,QuJ*,LiuGH*.DJ-1isDispensableforHumanStemCellHomeostasis.ProteinCell.2019.10(11):846-853.

FuL,HuY,SongM,LiuZ,ZhangW,YuFX,WuJ,WangS,BelmonteJC,ChanP,QuJ*,TangF*,LiuGH*.UpregulationofFOXD1byYAPAlleviatesSenescenceandOsteoarthritis.PLoSBiology.2019.17(4):e3000201.

LingC,LiuZ,SongM,ZhangW,WangS,LiuX,MaS,SunS,FuL,ChuQ,BelmonteJC,WangZ,QuJ*,YuanY*,LiuGH*.ModelingCADASILVascularPathologieswithPatient-DerivedInducedPluripotentStemCells.ProteinCell.2019.10(4):249-271.

RenX,HuB,SongM,DingZ,DangY,LiuZ,ZhangW,JiQ,RenR,DingJ,ChanP,JiangC,YeK,QuJ*,TangF*,LiuGH*.MaintenanceofNucleolarHomeostasisbyCBX4AlleviatesSenescenceandOsteoarthritis.CellReports.2019.26(13):3643-3656.

GengL,LiuZ,ZhangW*,LiW,WuZ,WangW,RenR,SuY,WangP,JuZ,ChanP,SongM*,QuJ*,LiuGH*.ChemicalScreenIdentifiesaGeroprotectiveRoleofQuercetininPrematureAging.ProteinCell.2019.10(6):417-435.

ZhangW,WanH,FengG,QuJ,WangJ,JingY,RenR,LiuZ,ZhangL,ChenZ,WangS,ZhaoY,WangZ,YuanY,ZhouQ,LiW*,LiuGH*,HuB*.SIRT6DeficiencyResultsinDevelopmentalRetardationinCynomolgusMonkeys.Nature.2018.560(7720):661-665.(Leadingcontact)

WangS,HuB,DingZ,DangY,WuJ,LiD,LiuX,XiaoB,ZhangW,RenR,LeiJ,HuH,ChenC,ChanP,LiD,QuJ*,TangF*,LiuGH*.ATF6SafeguardsOrganelleHomeostasisandCellularAginginHumanMesenchymalStemCells.CellDiscovery.2018.Jan5;4:2.

FangJ,YangJ,WuX,ZhangG,LiT,ZhangH,WangCC,LiuGH*,WangL*.MetforminAlleviatesHumanCellularAgingbyUpregulatingtheERPeroxidaseGPx7.AgingCell.2018.17(4):e12765.

WuZ,ZhangW,SongM,WangW,WeiG,LiW,LeiJ,HuangY,SangY,ChanP,ChenC,QuJ*,SuzukiK*,BelmonteJC*,LiuGH*.DifferentialStemCellAgingKineticsinHutchinson–GilfordProgeriaSyndromeandWernerSyndrome.ProteinCell.2018.9(4):333-350.(Coverstory)

RenR,DengL,XueY,SuzukiK,ZhangW,YuY,WuJ,SunL,GongX,LuanH,YangF,JuZ,RenX,WangS,TangH,GengL,ZhangW,LiJ,QiaoJ,XuT*,QuJ*,LiuGH*.VisualizationofAging-associatedChromatinAlterationswithanEngineeredTaleSystem.CellResearch.2017.27(4):483-504.(Coverstory)

YangJ,LiJ,SuzukiK,LiuX,WuJ,ZhangW,RenR,ZhangW,ChanP,BelmonteJC,QuJ*,TangF*,LiuGH*.GeneticEnhancementinCulturedHumanAdultStemCellsConferredbyaSingleNucleotideRecoding.CellResearch.2017.27(9):1178-1181.

WangL,YiF,FuL,YangJ,WangS,WangZ,SuzukiK,SunL,XuX,YuY,QiaoJ,BelmonteJC,YangZ,YuanY*,QuJ*,LiuGH*.CRISPR/Cas9-MediatedTargetedGeneCorrectioninAmyotrophicLateralSclerosisPatientiPSCs.ProteinCell.2017.8(5):365-378.(Coverstory)

KubbenN,ZhangW,WangL,VossT,YangJ,QuJ,LiuGH*,MisteliT*,RepressionoftheAntioxidantNRF2PathwayinPrematureAging.Cell.2016.165(6):1361-1374.

PanH,GuanD,LiuX,LiJ,WangL,WuJ,ZhouJ,ZhangW,RenR,ZhangW,LiY,YangJ,HaoY,YuanT,YuanG,WangH,JuZ,MaoZ,LiJ,QuJ*,TangF*,LiuGH*.SIRT6SafeguardsHumanMesenchymalStemCellsFromOxidativeStressbyCoactivatingNRF2.CellResearch.2016.26(2):190-205.

SuzukiK,TsunekawaY,Hernandez-BenitezR,WuJ,ZhuJ,KimEJ,HatanakaF,YamamotoM,AraokaT,LiZ,KuritaM,HishidaT,LiM,AizawaE,GuoS,ChenS,GoeblA,SoligallaRD,QuJ,JiangT,FuX,JafariM,EstebanCR,BerggrenWT,LajaraJ,Nuñez-DelicadoE,GuillenP,CampistolJM,MatsuzakiF,LiuGH,MagistrettiP,ZhangK,CallawayEM,ZhangK,BelmonteJC.InVivoGenomeEditingviaCRISPR/Cas9MediatedHomology-IndependentTargetedIntegration.Nature.2016.540(7631):144-149.

FuL,XuX,RenR,WuJ,ZhangW,YangJ,RenX,WangS,ZhaoY,SunL,YuY,WangZ,YangZ,YuanY,QiaoJ,BelmonteJC*,QuJ*,LiuGH*.ModelingXerodermaPigmentosumAssociatedNeurologicalPathologieswithPatients-DerivediPSCs.ProteinCell.2016.7(3):210-221.

WangH,DiaoD,ShiZ,ZhuX,GaoY,GaoS,LiuX,WuY,RudolphKL,LiuGH,LiT,JuZ.SIRT6ControlsHematopoieticStemCellHomeostasisthroughEpigeneticRegulationofWntSignaling.CellStemCell.2016.7;18(4):495-507.

LiY,ZhangW,ChangL,HanY,SunL,GuoX,TangH,LiuZ,DengH,YeY,RenR,WangY,LiJ,QiaoJ,QuJ*,ZhangW*,LiuGH*.VitaminCAlleviatesAgingDefectsinaStemCellModelforWernerSyndrome.ProteinCell.2016.7(7):478-488.(Coverstory)

ZhangW,LiJ,SuzukiK,QuJ,WangP,ZhouJ,LiuX,RenR,XuX,OcampoA,YuanT,YangJ,LiY,ShiL,GuanD,PanH,DuanS,DingZ,LiM,YiF,BaiR,WangY,ChenC,YangF,LiX,WangZ,AizawaE,GoeblA,SoligallaRD,ReddyP,EstebanCR,TangF*,LiuGH*,BelmonteJC*.AWernerSyndromeStemCellModelUnveilsHeterochromatinAlterationsasaDriverofHumanAging.Science.2015;348(6239):1160-1163.

ReddyP,OcampoA,SuzukiK,LuoJ,BacmanSR,WilliamsSL,SugawaraA,OkamuraD,TsunekawaY,WuJ,LamD,XiongX,MontserratN,EstebanCR,LiuGH,Sancho-MartinezI,ManauD,CivicoS,CardellachF,DelMarO'CallaghanM,CampistolJ,ZhaoH,CampistolJM,MoraesCT,IzpisuaBelmonteJC.SelectiveEliminationofMitochondrialMutationsintheGermlinebyGenomeEditing.Cell.2015;161(3):459-469.

DuanS,YuanG,LiuX,RenR,LiJ,ZhangW,WuJ,XuX,FuL,LiY,YangJ,ZhangW,BaiR,YiF,SuzukiK,GaoH,EstebanCR,ZhangC,BelmonteJC,ChenZ,WangX,JiangT,QuJ*,TangF*,LiuGH*.PTENDeficiencyReprogramsHumanNeuralStemCellsTowardsaGlioblastomaStemCell-LikePhenotype.NatureCommunications.2015.6:10068.