裴正康,1951年8月出生于中国台湾,台湾中央研究院院士、中国工程院外籍院士,美国圣述德儿童研究医院肿瘤系主任。1976年裴正康获得台湾大学医学博士学位;1977年在美国St.Jude儿童研究医院从事儿童白血病的研究和治疗;2014年,当选台湾中央研究院院士;2015年当选为中国工程院外籍院士。裴正康长期从事儿童肿瘤临床与研究工作。
基本资料
中文名:裴正康
外文名:ChingHonPui
国籍:中国
民族:汉族
出生地:中国台湾
出生日期:1951年8月
毕业院校:台湾大学
职业:教育科研工作者
主要成就:2014年当选中国台湾中央研究院院士
2015年当选为中国工程院外籍院士
人物经历
1951年8月,裴正康出生于中国台湾。
1969年,从香港培正中学毕业后,以侨生身份到台湾大学就读。
1976年,裴正康获得台湾大学医学博士学位。
1977年,在美国St.Jude儿童研究医院从事儿童白血病的研究和治疗。
1990年,历任美国田纳西大学医学院、圣洁德儿童研究医院血液/肿瘤科教授、儿科学教授。
2014年,当选中国台湾中央研究院院士。
2015年,当选为中国工程院外籍院士。
主要成就
裴正康科研成就
科研综述
裴正康研究和论证的临床研究成果使儿童急性淋巴细胞白血病(ALL)的治愈率超过90%,受益群体由儿童扩展至青少年;率先提出并论证儿童ALL可以通过鞘内化疗和大剂量甲氨蝶呤化疗替代头颅放疗,使全球无数的ALL患儿免受头颅放疗和由此带来的相关近、远期合并症,并因此而使患儿终身受益;率先论证了表鬼臼类毒素可导致二次肿瘤,使全球相关癌症患者受益;创新性地识别白血病相关的特异靶基因并作为治疗靶标使部分难治性ALL得到有效的治疗。证明白血病微量残留病水平监测可指导临床治疗强度的调整,该治疗策略得到全球性认可并广泛应用。
学术论著
据2019年8月中国工程院官网显示,裴正康原创论著718篇,被引41404次,仅第一作者NEngJMed10篇。
PuiCH.Todelayornottodelay,thatisthequestionforpatientswithacutelymphoblasticleukemiawhodonotreceiveprophylacticcranialirradiation.CancerOct10,2018.doi:10.1002/cncr.31756
PuiCH,YangJJ,BhaktaN,Rodriguez-GalindoC.Globaleffortstowardthecureofchildhoodacutelymphoblasticleukaemia.LancetChildAdolescHealthJun;2(6):440-454,2018.doi:10.1016/S2352-4642(18)30066-X
PuiCH.Istesticularirradiationnecessaryforpatientswithacutelymphoblasticleukemiaandtesticularrelapse?PediatrBloodCancerMay;65(5):e26977,2018.doi:10.1002/pbc.26977
PuiCH,LiuY,RellingMV.Howtosolvetheproblemofhypersensitivitytoasparaginase?PediatrBloodCancerMar;65(3),2018.PMCID:PMC5766401
PuiCH,CampanaD.MinimalresidualdiseaseinpediatricALL.OncotargetSep13;8(45):78251-78252,2017.PMCID:PMC5667954
PuiCH,RobertsKG,YangJJ,MullighanCG.Philadelphiachromosome-likeacutelymphoblasticleukemia.ClinLymphomaMyelomaLeukAug;17(8):464-470,2017.PMCID:PMC5638138
PuiCH,PeiD,RaimondiSC,Coustan-SmithE,JehaS,ChengC,BowmanWP,SandlundJT,RibeiroRC,RubnitzJE,InabaH,GruberTA,LeungWH,YangJJ,DowningJR,EvansWE,RellingMV,CampanaD.Clinicalimpactofminimalresidualdiseaseinchildrenwithdifferentsubtypesofacutelymphoblasticleukemiatreatedwithresponse-adaptedtherapy.LeukemiaFeb;31(2):333-339,2017.PMCID:PMC5288281
PuiCH.IsErwinaseNecessaryforallChildrenWithALLandAllergicReactionstoE.coliAsparaginase?PediatrBloodCancerApr;63(4):587-588,2016.PMCID:PMC4755852
PuiCH,YangJJ,HungerSP,PietersR,SchrappeM,BiondiA,VoraA,BaruchelA,SilvermanLB,SchmiegelowK,EscherichG,HoribeK,BenoitYC,IzraeliS,YeohAE,LiangDC,DowningJR,EvansWE,RellingMV,MullighanCG.ChildhoodAcuteLymphoblasticLeukemia:progressthroughcollaboration.JClinOncol33(27):2938-48,2015.
PuiCH,PeiD,Coustan-SmithE,JehaS,ChengC,BowmanWP,SandlundJT,RibeiroRC,RubnitzJE,InabaH,BhojwaniD,GruberTA,LeungWH,DowningJR,EvansWE,RellingMV,CampanaD.Clinicalutilityofsequentialminimalresidualdiseasemeasurementsinthecontextofrisk-basedtherapyinchildhoodacutelymphoblasticleukaemia:aprospectivestudy.LancetOncol16(4):465-474,2015.
ZhangJ,WalshMF,WuG,EdmonsonMN,GruberTA,EastonJ,HedgesD,MaX,ZhouX,YergeauDA,WilkinsonMR,VadodariaB,ChenX,McGeeRB,Hines-DowellS,NuccioR,QuinnE,ShurtleffSA,RuschM,PatelA,BecksfortJB,WangS,WeaverMS,DingL,MardisER,WilsonRK,GajjarA,EllisonDW,PappoAS,PuiCH,NicholsKE,DowningJR.GermlineMutationsinPredispositionGenesinPediatricCancer.NEnglJMed373(24):2336-46,2015.
MullighanCG,JehaS,PeiD,Payne-TurnerD,Coustan-SmithE,RobertsKG,WaandersE,ChoiJK,MaX,RaimondiSC,FanY,YangW,SongG,YangJJ,InabaH,DowningJR,LeungWH,BowmanWP,RellingMV,EvansWE,ZhangJ,CampanaD,PuiCH.OutcomeofchildrenwithhypodiploidALLtreatedwithrisk-directedtherapybasedonMRDlevels.Blood2015Nov2.pii:blood-2015-09-671131.
PuiCH,PeiD,CampanaD,ChengC,SandlundJT,BowmanWP,HudsonMM,RibeiroRC,RaimondiSC,JehaS,HowardSC,BhojwaniD,InabaH,RubnitzJE,MetzgerML,GruberTA,Coustan-SmithE,DowningJR,LeungWH,RellingMV,EvansWE.Areviseddefinitionforcureofchildhoodacutelymphoblasticleukemia.Leukemia28(12):2336-43,2014.
RobertsKG,PeiD,CampanaD,Payne-TurnerD,LiY,ChengC,SandlundJT,JehaS,EastonJ,BecksfortJ,ZhangJ,Coustan-SmithE,RaimondiSC,LeungWH,RellingMV,EvansWE,DowningJR,MullighanCG,PuiCH.OutcomeofchildrenwithBCR-ABL1-likeacutelymphoblasticleukemiatreatedwithrisk-directedtherapybasedonthelevelsofminimalresidualdisease.JClinOncol32(27):3012-20,2014.
YeohAE,TanD,LiCK,HoriH,TseE,PuiCH.ManagementofadultandpaediatricacutelymphoblasticleukaemiainAsia:resource-stratifiedguidelinesfromtheAsiaOncologySummit2013.LancetOncol14:e508-523,2013.
PuiCH,EvansWE.A50-yearjourneytocurechildhoodacutelymphoblasticleukemia.SeminHematol50(3):185-96,2013.
KrullKR,BhojwaniD,ConklinHM,PeiD,ChengC,ReddickWE,SandlundJT,PuiCH.Geneticmediatorsofneurocognitiveoutcomesinsurvivorsofchildhoodacutelymphoblasticleukemia.JClinOncol31(17):2182-2188,2013.
BhojwaniD,PuiCH.Relapsedchildhoodacutelymphoblasticleukaemia.LancetOncol14(6):e205-17,2013.
PuiCH,MullighanCG,EvansWE,RellingMV.Pediatricacutelymphoblasticleukemia:wherearewegoingandhowdowegetthere?BloodJune22,2012.
DowningJR,WilsonRK,ZhangJ,MardisER,PuiCH,DingL,LeyTJ,EvansWE.Thepediatriccancergenomeproject.NatGenet44(6):619-22,2012.
PuiCH,PeiD,PappoAS,HowardSC,ChengC,SandlundJT,FurmanWL,RibeiroRC,SpuntSL,RubnitzJE,JehaS,HudsonMM,KunLE,MerchantTE,KocakM,BroniscerA,MetzgerML,DowningJR,LeungW,EvansWE,GajjarA.Treatmentoutcomesinblackandwhitechildrenwithcancer:resultsfromtheSEERdatabaseandStJudeChildren'sResearchHospital,1992through2007.JClinOncolApril30,2012.
LeungW,PuiCH,Coustan-SmithE,YangJ,PeiD,GanK,SrinivasanA,HartfordC,TriplettBM,DallasM,PillaiA,ShookD,RubnitzJE,SandlundJT,JehaS,InabaH,RibeiroRC,HandgretingerR,LaverJH,CampanaD.Detectableminimalresidualdiseasebeforehematopoieticcelltransplantationisprognosticbutdoesnotprecludecureforchildrenwithvery-high-riskleukemia.BloodApril19,2012.
SchrappeM,HungerSP,PuiCH,SahaV,GaynonPS,BaruchelA,ConterV,OttenJ,OharaA,VersluysAB,EscherichG,HeymanM,SilvermanLB,HoribeK,MannG,CamittaBM,HarbottJ,RiehmH,RichardsS,DevidasM,ZimmermannM.Outcomesafterinductionfailureinchildhoodacutelymphoblasticleukemia.NEnglJMed366(15):1371-81,2012.
ZhangJ,DingL,HolmfeldtL,WuG,HeatleySL,Payne-TurnerD,EastonJ,ChenX,WangJ,RuschM,LuC,ChenSC,WeiL,Collins-UnderwoodJR,MaJ,RobertsKG,PoundsSB,UlyanovA,BecksfortJ,GuptaP,HuetherR,KriwackiRW,ParkerM,McGoldrickDJ,ZhaoD,AlfordD,EspyS,BobbaKC,SongG,PeiD,ChengC,RobertsS,BarbatoMI,CampanaD,Coustan-SmithE,ShurtleffSA,RaimondiSC,KleppeM,CoolsJ,ShimanoKA,HermistonML,DoulatovS,EppertK,LaurentiE,NottaF,DickJE,BassoG,HungerSP,LohML,DevidasM,WoodB,WinterS,DunsmoreKP,FultonRS,FultonLL,HongX,HarrisCC,DoolingDJ,OchoaK,JohnsonKJ,ObenauerJC,EvansWE,PuiCH,NaeveCW,LeyTJ,MardisER,WilsonRK,DowningJR,MullighanCG.ThegeneticbasisofearlyT-cellprecursoracutelymphoblasticleukaemia.Nature481(7380):157-63,2012.
DioufB,ChengQ,KrynetskaiaNF,YangW,CheokM,PeiD,FanY,ChengC,KrynetskiyEY,GengH,ChenS,ThierfelderWE,MullighanCG,DowningJR,HsiehP,PuiCH,RellingMV,EvansWE.SomaticdeletionsofgenesregulatingMSH2proteinstabilitycauseDNAmismatchrepairdeficiencyanddrugresistanceinhumanleukemiacells.NatMed17(10):1298-1303,2011.
LeungW,CampanaD,YangJ,PeiD,Coustan-SmithE,GanK,RubnitzJE,SandlundJT,RibeiroRC,SrinivasanA,HartfordC,TriplettBM,DallasM,PillaiA,HandgretingerR,LaverJH,PuiCH.Highsuccessofhematopoieticcelltransplantationregardlessofdonorsourceinchildrenwithveryhigh-riskleukemia.BloodMay25,2011.
HowardSC,JonesDP,PuiCH.Thetumorlysissyndrome.NEnglJMed364(19):1844-54,2011.
MullighanCG,ZhangJ,KasperLH,LerachS,Payne-TurnerD,PhillipsLA,HeatleySL,HolmfeldtL,Collins-UnderwoodJR,MaJ,BuetowKH,PuiCH,BakerSD,BrindlePK,DowningJR.CREBBPmutationsinrelapsedacutelymphoblasticleukaemia.Nature471(7337):235-9,2011.
YangJJ,ChengC,DevidasM,CaoX,FanY,CampanaD,YangW,NealeG,CoxNJ,ScheetP,BorowitzMJ,WinickNJ,MartinPL,WillmanCL,BowmanWP,CamittaBM,CarrollA,ReamanGH,CarrollWL,LohM,HungerSP,PuiCH,EvansWE,RellingMV.Ancestryandpharmacogenomicsofrelapseinacutelymphoblasticleukemia.NatGenetFebruary6,2011.
PuiCH,CarrollWL,MeshinchiS,ArceciRJ.Biology,riskstratification,andtherapyofpediatricacuteleukemias:anupdate.JClinOncolJanuary1,2011.
裴正康人才培养
截至2015年12月,裴正康张罗其所在的医院先后提供资助、培训了100多个中国儿童肿瘤专业人员。
裴正康荣誉表彰
社会任职
2016年5月27日,被聘为中国医学科学院血液学研究所荣誉教授。
2017年10月30日,被聘为广州医科大学儿科学院、广州市妇女儿童医疗中心荣誉客座教授。
人物评价
提升中国儿童白血病诊疗水平,推动中国儿科医学新体系建设,裴正康功不可没。(同济大学关工委评)
裴正康带着永不疲倦的精神和儿童白血病征战。(Evans医师评)
裴正康教授在儿童急性淋巴母细胞癌方面的研究有很大的贡献。(田纳西新闻评)